| Drug General Information |
| Drug ID |
D05VVC
|
| Former ID |
DNC012434
|
| Drug Name |
7-chloro-3-hydroxyquinazoline-2,4-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H5ClN2O3
|
| Canonical SMILES |
C1=CC2=C(C=C1Cl)NC(=O)N(C2=O)O
|
| InChI |
1S/C8H5ClN2O3/c9-4-1-2-5-6(3-4)10-8(13)11(14)7(5)12/h1-3,14H,(H,10,13)
|
| InChIKey |
CRTPJJNXJPKDEZ-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Glutamate receptor 1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Glutamate [NMDA] receptor subunit epsilon 2 |
Target Info |
Inhibitor |
[1]
|
| Glutamate [NMDA] receptor subunit epsilon 1 |
Target Info |
Inhibitor |
[1]
|
| Glutamate receptor AMPA subtype |
Target Info |
Inhibitor |
[1]
|
| NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Dopaminergic synapse
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Long-term depression
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Amyotrophic lateral sclerosis (ALS)
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Amphetamine addiction
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Nicotine addictionhsa04014:Ras signaling pathway
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Rap1 signaling pathway
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Alzheimer's disease
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Huntington's disease
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Cocaine addiction
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Nicotine addiction
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Alcoholism
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Systemic lupus erythematosushsa04014:Ras signaling pathway
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Calcium signaling pathway
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PANTHER Pathway
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathwayP00029:Huntington disease
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Pathway Interaction Database
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EPHB forward signalingerbb4_pathway:ErbB4 signaling events
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Reelin signaling pathwayreelinpathway:Reelin signaling pathway
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Reactome
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COPII (Coat Protein 2) Mediated Vesicle Transport
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Trafficking of AMPA receptors
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Trafficking of GluR2-containing AMPA receptors
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Unblocking of NMDA receptor, glutamate binding and activation
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Cargo concentration in the ERR-HSA-3928662:EPHB-mediated forward signaling
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
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RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
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RAF/MAP kinase cascade
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WikiPathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Amyotrophic lateral sclerosis (ALS)
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BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
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Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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| References |
| REF 1 | J Med Chem. 2006 Oct 5;49(20):6015-26.Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. |
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