Drug Information

Drug General Information
Drug ID
D05WKI
Former ID
DNC009397
Drug Name
UCM-454
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542735]
Structure
Download
2D MOL

3D MOL
Formula
C20H21ClN2O2
InChI
InChI=1S/C20H21ClN2O2/c1-3-20(24)22-12-16-11-17-18(5-4-6-19(17)25-2)23(16)13-14-7-9-15(21)10-8-14/h4-11H,3,12-13H2,1-2H3,(H,22,24)
InChIKey
XXXKKZBZKUDKMA-UHFFFAOYSA-N
PubChem Compound ID
10428383
PubChem Substance ID
15447817, 22769743, 40556051, 79301878, 103206654, 104098289, 223366116, 247670223
Target and Pathway
Target(s) Melatonin receptor type 1B Target Info Inhibitor [529949]
Melatonin receptor Target Info Inhibitor [529949]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainmenthsa04080:Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 542735(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7783).
Ref 529949J Med Chem. 2009 Feb 12;52(3):826-33.2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.

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