Drug General Information
Drug ID	D05XLO
Former ID	DCL000134
Drug Name	INCB13739
Drug Type	Small molecular drug
Indication	Type 2 diabetes [ICD9: 250; ICD10:E11]		Phase 2a	[522347]
	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Phase 2	[522347]
Company	Incyte
Structure		Download 2D MOL 3D MOL
Formula	C6H5AsO
Canonical SMILES	C1=CC=C(C=C1)[As]=O
InChI	1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
InChIKey	BQVCCPGCDUSGOE-UHFFFAOYSA-N
PubChem Compound ID	4778
PubChem Substance ID	97034, 630901, 3137510, 6752686, 8152934, 15321835, 24898387, 26759339, 29223862, 49834324, 49871838, 53787614, 57322444, 78628055, 85088620, 87574393, 88833008, 103639549, 103843612, 104307400, 117357194, 134338816, 134340358, 134978308, 135562904, 137006306, 142276159, 144211636, 151979814, 162091628, 163687514, 163835449, 176329210, 179148757, 198957874, 201506311, 204361893, 212344127, 226523248, 226684484, 241114067, 249626677, 250033911, 252503034
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[551127]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 522347	ClinicalTrials.gov (NCT00698230) Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics. U.S. National Institutes of Health.
Ref 551127	Incyte's Selective Oral Inhibitor Of 11beta-HSD1 Demonstrates Improvements In Insulin Sensitivity And Lowers Cholesterol Levels In Type 2 Diabetics. Incyte. 2008.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.