Drug Information

Drug General Information
Drug ID
D05XOJ
Former ID
DNC000975
Drug Name
N-(3-(aminosulfonyl)-4-chloro-2-hydroxyphenyl)-N'-(2,3-dichlorophenyl) urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535612]
Structure
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2D MOL

3D MOL
Formula
C13H10Cl3N3O4S
Canonical SMILES
C1=CC(=C(C(=C1)Cl)Cl)NC(=O)NC2=C(C(=C(C=C2)Cl)S(=O)(=O)<br />N)O
InChI
1S/C13H10Cl3N3O4S/c14-6-2-1-3-8(10(6)16)18-13(21)19-9-5-4-7(15)12(11(9)20)24(17,22)23/h1-5,20H,(H2,17,22,23)(H2,18,19,21)
InChIKey
WTLRWOHEKQGKDS-UHFFFAOYSA-N
PubChem Compound ID
9887803
PubChem Substance ID
14855342, 24174054, 45634742, 49684212, 53790519, 76587477, 129631760, 134340252, 134340503, 135357762, 138061977, 223812643, 227736351
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [535612]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 535612A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002 Dec 1;169(11):6435-44.
Ref 535612A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002 Dec 1;169(11):6435-44.

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