Drug Information

Drug General Information
Drug ID
D05XZF
Former ID
DNC000368
Drug Name
BX 471
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542648]
Structure
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2D MOL

3D MOL
Formula
C21H24ClFN4O3
InChI
InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
InChIKey
XQYASZNUFDVMFH-CQSZACIVSA-N
PubChem Compound ID
512282
PubChem Substance ID
813645, 8668399, 14832479, 14930200, 38696340, 62644955, 76737069, 103532771, 104060493, 104085911, 109744565, 129728212, 134344942, 135650045, 140156777, 163642055, 163783410, 170481111, 198976121, 210274757, 210280390, 230502099, 241376473, 249691159, 252157302, 252160713, 252451424, 252478033
Target and Pathway
Target(s) C-C chemokine receptor type 1 Target Info Antagonist [534976]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway IL5 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542648(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 767).
Ref 534976Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.

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