Drug Information

Drug General Information
Drug ID
D05YFL
Former ID
DIB007675
Drug Name
AFTVac
Synonyms
Autologous fixed tumor vaccine (AFTVac) therapy; Autologous vaccine (cancer), Cell-Medicine; GM-CSF agonist/IL-2 agonist containing-vaccine; Fixed autologous tumor derivatives + microparticles encapsulating GM-CSF and IL-2, Cell-Medicine
Drug Type
Vaccine
Indication Glioblastoma multiforme [ICD9: 191; ICD10:C71] Phase 2 [526997]
Company
Cell-Medicine Inc
Target and Pathway
Target(s) Granulocyte-macrophage colony-stimulating factor receptor alpha chain Target Info [526997]
Interleukin-2 receptor subunit beta Target Info [526997]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancerhsa04060:Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Measles
HTLV-I infection
Transcriptional misregulation in cancer
NetPath Pathway IL3 Signaling Pathway
RANKL Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Alpha9 beta1 integrin signaling eventsil12_2pathway:IL12-mediated signaling events
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Downstream signaling in na&#xef
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-3, 5 and GM-CSF signaling
RAF/MAP kinase cascade
Surfactant metabolism
Interleukin receptor SHC signalingR-HSA-114604:GPVI-mediated activation cascade
Interleukin-2 signaling
Interleukin receptor SHC signaling
WikiPathways Interleukin-2 signaling
Interleukin-3, 5 and GM-CSF signalingWP49:IL-2 Signaling Pathway
Inflammatory Response Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 526997Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9.
Ref 526997Phase II randomized trial of autologous formalin-fixed tumor vaccine for postsurgical recurrence of hepatocellular carcinoma. Clin Cancer Res. 2004 Mar 1;10(5):1574-9.

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