Drug Information

Drug General Information
Drug ID
D05YLL
Former ID
DIB011136
Drug Name
FL-386
Synonyms
Benzene sulfonic acid 2-(trans-4-isobutylcyclohexyl)-2-oxoethyl ester
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [545143]
Structure
Download
2D MOL

3D MOL
Formula
C18H26O4S
Canonical SMILES
CC(C)CC1CCC(CC1)C(=O)COS(=O)(=O)C2=CC=CC=C2
InChI
1S/C18H26O4S/c1-14(2)12-15-8-10-16(11-9-15)18(19)13-22-23(20,21)17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3
InChIKey
RLVLLBHWAQWLKL-UHFFFAOYSA-N
CAS Number
CAS 84856-18-8
PubChem Compound ID
134847
PubChem Substance ID
10243766, 14924744, 15446567, 29312479, 79898789, 103104738, 104383123, 117634949, 125678269, 129147953, 129147954, 135091240, 137076885, 162921611, 227360647, 231801718, 241148755
Target and Pathway
Target(s) Dihydropyrimidine dehydrogenase [NADP+] Target Info Modulator [531635], [533903]
BioCyc Pathway Pyrimidine ribonucleosides degradation
Thymine degradation
Uracil degradation
KEGG Pathway Pyrimidine metabolism
beta-Alanine metabolism
Pantothenate and CoA biosynthesis
Drug metabolism - other enzymes
Metabolic pathways
PANTHER Pathway Pyrimidine Metabolism
PathWhiz Pathway Beta-Alanine Metabolism
Pyrimidine Metabolism
WikiPathways Metabolism of nucleotides
Fluoropyrimidine Activity
References
Ref 545143Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002285)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 533903Effects of FL-386 on faecal lipid excretion in humans. J Int Med Res. 1993 Sep-Oct;21(5):225-33.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.