Drug General Information
Drug ID	D05ZIP
Former ID	DNC007640
Drug Name	(4-bromo-1H-pyrazol-1-yl)(p-tolyl)methanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529037]
Structure		Download 2D MOL 3D MOL
Formula	C11H9BrN2O
Canonical SMILES	CC1=CC=C(C=C1)C(=O)N2C=C(C=N2)Br
InChI	1S/C11H9BrN2O/c1-8-2-4-9(5-3-8)11(15)14-7-10(12)6-13-14/h2-7H,1H3
InChIKey	ZIILQHVFVJLRAB-UHFFFAOYSA-N
PubChem Compound ID	674656
Target and Pathway
Target(s)	Plasma kallikrein	Target Info	Inhibitor	[529037]
	Coagulation factor IIa	Target Info	Inhibitor	[529037]
	Leukocyte elastase	Target Info	Inhibitor	[529037]
	Urokinase-type plasminogen activator	Target Info	Inhibitor	[529037]
KEGG Pathway	Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeletonhsa05202:Transcriptional misregulation in cancer
	Systemic lupus erythematosushsa04064:NF-kappa B signaling pathway
	Transcriptional misregulation in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
NetPath Pathway	AndrogenReceptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Blood coagulationP00011:Blood coagulationP00011:Blood coagulation
	Plasminogen activating cascade
	CCKR signaling map ST
Pathway Interaction Database	Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor networkintegrin1_pathway:Beta1 integrin cell surface interactions
	E2F transcription factor network
	Beta3 integrin cell surface interactions
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	amb2 Integrin signaling
	ATF-2 transcription factor network
	AP-1 transcription factor network
	Beta2 integrin cell surface interactions
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
	FGF signaling pathway
PathWhiz Pathway	CoagulationPW000047:Vitamin K Metabolism
	Coagulation
Reactome	Intrinsic Pathway of Fibrin Clot Formation
	Activation of Matrix MetalloproteinasesR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)R-HSA-1442490:Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix MetalloproteinasesR-HSA-75205:Dissolution of Fibrin Clot
WikiPathways	Complement and Coagulation Cascades
	Human Complement System
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient NetworkWP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Degradation of collagenWP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Endochondral Ossification
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Dissolution of Fibrin Clot
	Osteopontin Signaling
References
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

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