Drug Information

Drug General Information
Drug ID
D05ZQV
Former ID
DIB002485
Drug Name
NK-611
Synonyms
2''-Deoxy-2''-(dimethylamino)etoposide
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545190]
Structure
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2D MOL

3D MOL
Formula
C31H37NO12
Canonical SMILES
COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(OC4OC5COC(C)OC<br />5C(O)C4N)c6cc7OCOc7cc26
InChI
1S/C29H33NO12/c1-11-36-9-20-27(40-11)25(32)23(30)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)24(31)19(5-12)35-3/h4-7,11,15,20-23,25-27,29,31-32H,8-10,30H2,1-3H3/t11?,15?,20?,21-,22+,23?,25?,26?,27?,29?/m1/s1
InChIKey
FBXXLRBLSSYWAA-WXRMPKHTSA-N
CAS Number
CAS 105655-99-0
PubChem Compound ID
6917988
Target and Pathway
Target(s) DNA topoisomerase I Target Info Inhibitor [534608]
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 545190Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002418)
Ref 534608DNA topoisomerase II poisons and inhibitors. Cancer Chemother Biol Response Modif. 1997;17:114-31.

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