Drug Information

Drug General Information
Drug ID
D05ZSX
Former ID
DIB004863
Drug Name
NN-8828
Synonyms
NNC-114-0005; NNC-0114-0000-0005; Anti-IL-21 (inflammation), Novo Nordisk; MIL-21 monoclonal antibody (autoimmune/chronic inflammatory disease), ZymoGenetics; Anti-IL-21 mAb (autoimmune/chronic inflammatory disease), Novo Nordisk; Anti-IL-21 mAb (autoimmune/chronic inflammatory disease), ZymoGenetics; Anti-IL-21 monoclonal antibody (autoimmune/chronic inflammatory disease), ZymoGenetics
Drug Type
Antibody
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1 [523183]
Company
ZymoGenetics Inc
Target and Pathway
Target(s) IL-21 Target Info [551834]
KEGG Pathway Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Inflammatory bowel disease (IBD)
PANTHER Pathway Interleukin signaling pathway
WikiPathways Allograft Rejection
References
Ref 523183ClinicalTrials.gov (NCT01208506) First-in-Man Trial of NNC114-0005 in Healthy Subjects and Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 551834Handbook of Therapeutic Antibodies. 2014. 1. Page(995).

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