Drug Information

Drug General Information
Drug ID
D05ZXZ
Former ID
DNC000277
Drug Name
BAY 57-1293
Drug Type
Small molecular drug
Indication Herpes simplex virus infection [ICD9: 54; ICD10:B00] Phase 2 [524007]
Structure
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2D MOL

3D MOL
Formula
C18H18N4O3S2
Canonical SMILES
CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=<br />O)N
InChI
1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)
InChIKey
IVZKZONQVYTCKC-UHFFFAOYSA-N
PubChem Compound ID
491941
PubChem Substance ID
652431, 10312115, 14805940, 38680050, 50360989, 109757165, 134339742, 135273248, 137099058, 139300870, 172918201, 189423050, 198043966, 198969942, 210275213, 210280852, 223396440, 223844731, 227321144, 242059801, 247869540, 249738350, 251910830, 252160875, 252451616, 252553871
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Herpes simplex virus helicase-primase Target Info Inhibitor [535990]
References
Ref 524007ClinicalTrials.gov (NCT01658826) Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes. U.S. National Institutes of Health.
Ref 535990Helicase primase: targeting the Achilles heel of herpes simplex viruses. Antivir Chem Chemother. 2004 May;15(3):135-40.

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