Drug Information

Drug General Information
Drug ID
D06AIN
Former ID
DIB018406
Drug Name
[3H]S-15535
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540178]
Structure
Download
2D MOL
Formula
C21H24N2O2
InChI
InChI=1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
InChIKey
QJPPEMXOOWNICQ-UHFFFAOYSA-N
PubChem Compound ID
132787
PubChem Substance ID
10243194, 14900073, 26753615, 26753616, 29215165, 29310835, 48179689, 48253921, 57344259, 79460343, 85209810, 90340566, 103232002, 104378207, 121361753, 125820975, 134221970, 135087833, 135650960, 135651202, 136350534, 140448560, 144239784, 162223633, 162312694, 162793530, 163564828, 175612588, 179235771, 184538700, 204360580, 224956703, 227839306, 245590360, 252322750, 252815017
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534606]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540178(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 32).
Ref 534606Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Naunyn Schmiedebergs Arch Pharmacol. 1998 Mar;357(3):205-17.

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