Drug Information
Drug General Information | |||||
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Drug ID |
D06BUA
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Former ID |
DIB002912
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Drug Name |
Nexopamil
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Synonyms |
LU-49938
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Phase 2 | [1] | ||
Company |
BASF AG
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Structure |
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Download2D MOL |
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Formula |
C24H40N2O3
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Canonical SMILES |
c1([C@@](C#N)(C(C)C)CCCN(CCCCCC)C)cc(c(c(c1)OC)OC)OC
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Calcium channel | Target Info | Blocker | [1] | |
5-HT 2 receptor | Target Info | Modulator | [1] | ||
KEGG Pathway | Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | |||||
Gap junction | |||||
Serotonergic synapse | |||||
Inflammatory mediator regulation of TRP channels | |||||
References | |||||
REF 1 | Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94. | ||||
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