Drug Information

Drug General Information
Drug ID
D06BXT
Former ID
DIB018434
Drug Name
[3H]WIN55212-2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542381]
Structure
Download
2D MOL
Formula
C27H26N2O3
InChI
InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3
InChIKey
HQVHOQAKMCMIIM-UHFFFAOYSA-N
PubChem Compound ID
5689
PubChem Substance ID
5455586, 7980529, 8153488, 29224726, 47440499, 47736729, 48185207, 49992235, 57322895, 77916045, 85209355, 103065245, 103086020, 103856313, 104309968, 117565771, 125335448, 128100014, 135062074, 135081343, 135651216, 137746913, 160832906, 162787888, 163397139, 163844312, 172858107, 175608138, 179293804, 189659184, 204432480, 229675402, 242084306, 249967136, 252492187
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Agonist [534535]
Cannabinoid receptor 2 Target Info Agonist [533680]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 542381(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 736).
Ref 533680Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol Pharmacol. 1995 Aug;48(2):352-61.
Ref 534535Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1. J Neurochem. 1998 Jan;70(1):366-73.

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