Drug Information

Drug General Information
Drug ID
D06CGB
Former ID
DAP001209
Drug Name
Desogestrel
Synonyms
Cerazette; Desogen; Desogestrelum; Organon Brand of Desogestrel; ORG 2969; Desogestrelum [INN-Latin]; Desogestrel (USAN/INN); Desogestrel [USAN:BAN:INN]; Alpha-pregn-4-en-20-yn-17-ol, 13-Ethyl-11-methylene-18,19-dinor-17; (17alpha)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol; (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 17alpha-ethynyl-11-methylidene-18a-homo-estr-4-en-17beta-ol
Drug Type
Small molecular drug
Indication Hormonal contraceptives [ICD10:Z30] Approved [536361], [542071]
Therapeutic Class
Contraceptive Agents
Structure
Download
2D MOL

3D MOL
Formula
C22H30O
InChI
InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1
InChIKey
RPLCPCMSCLEKRS-BPIQYHPVSA-N
CAS Number
CAS 54024-22-5
PubChem Compound ID
40973
PubChem Substance ID
9831, 7849426, 7979047, 8176865, 12015338, 14923366, 14923367, 24702329, 34706666, 46505739, 48415858, 49963130, 50112703, 53787301, 56352943, 57312489, 71831485, 78875517, 92717926, 103566300, 104335749, 117391777, 126621867, 126653606, 126671043, 134338449, 135003936, 135727366, 136197332, 137002814, 140504081, 144206006, 152102617, 160963652, 162176918, 163133991, 164152385, 164756093, 175267238, 178103644, 179150590, 184552366, 196105624, 206246236, 223673205, 223974105, 226426388, 241094430
ChEBI ID
ChEBI:4453
SuperDrug ATC ID
G03AC09
SuperDrug CAS ID
cas=054024225
Target and Pathway
Target(s) Progesterone receptor Target Info Modulator [535085]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542071(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7065).
Ref 535085Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40.

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