| Drug General Information |
| Drug ID |
D06CWR
|
| Former ID |
DNC008625
|
| Drug Name |
4-(6-Methoxynaphthalen-2-yl)isoquinoline
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H15NO
|
| Canonical SMILES |
COC1=CC2=C(C=C1)C=C(C=C2)C3=CN=CC4=CC=CC=C43
|
| InChI |
1S/C20H15NO/c1-22-18-9-8-14-10-16(7-6-15(14)11-18)20-13-21-12-17-4-2-3-5-19(17)20/h2-13H,1H3
|
| InChIKey |
SGBOBLSELUHWRG-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[1]
|
|---|
| Cytochrome P450 11B1, mitochondrial |
Target Info |
Inhibitor |
[1]
|
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BioCyc Pathway
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Superpathway of steroid hormone biosynthesis
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Glucocorticoid biosynthesis
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Mineralocorticoid biosynthesis
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KEGG Pathway
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Steroid hormone biosynthesis
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Linoleic acid metabolism
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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Metabolic pathways
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Bile secretion
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Chemical carcinogenesishsa00140:Steroid hormone biosynthesis
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PathWhiz Pathway
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Caffeine Metabolism
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Retinol MetabolismPW000141:Steroidogenesis
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Reactome
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Xenobiotics
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Aflatoxin activation and detoxificationR-HSA-194002:Glucocorticoid biosynthesis
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Endogenous sterols
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WikiPathways
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Metapathway biotransformation
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Aflatoxin B1 metabolism
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Estrogen metabolism
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Benzo(a)pyrene metabolism
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Tamoxifen metabolism
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Tryptophan metabolism
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Oxidation by Cytochrome P450
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Nuclear Receptors in Lipid Metabolism and Toxicity
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Nuclear Receptors Meta-Pathway
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Farnesoid X Receptor Pathway
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Vitamin D Receptor Pathway
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Felbamate Metabolism
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Lidocaine metabolism
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Nifedipine Activity
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Colchicine Metabolic Pathway
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Irinotecan Pathway
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Drug Induction of Bile Acid Pathway
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Fatty Acid Omega Oxidation
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Codeine and Morphine MetabolismWP702:Metapathway biotransformation
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Metabolism of steroid hormones and vitamin D
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Corticotropin-releasing hormone
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| References |
| REF 1 | J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity. |
|---|
