| Drug General Information |
| Drug ID |
D06DGY
|
| Former ID |
DIB018058
|
| Drug Name |
(-)-N-porphynorapomorphine
|
| Synonyms |
(-)-N-porphynorapomorphine; n-propylapomorphine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C19H21NO2
|
| InChI |
InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
|
| InChIKey |
BTGAJCKRXPNBFI-OAHLLOKOSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
10256562, 12015717, 14751509, 24262969, 46241168, 47440561, 47440562, 47662551, 47736774, 47811040, 47885668, 47885669, 48110742, 48185254, 57351306, 75696986, 85788374, 90340979, 103066737, 103083645, 103512529, 103920697, 103925234, 113461331, 117618287, 124749713, 134349081, 135123718, 135650738, 138275992, 162807011, 179236235, 233548465
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Agonist |
[2]
|
|---|
| D(3) dopamine receptor |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
|
Cocaine addiction
|
|
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Dopamine receptor mediated signaling pathway
|
|
Nicotine pharmacodynamics pathway
|
|
Reactome
|
Dopamine receptors
|
|
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Hypothetical Network for Drug Addiction
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR ligand binding
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
|
|
Nicotine Activity on Dopaminergic Neurons
|
|
GPCRs, Other
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 969). |
|---|
| REF 2 | A functional test identifies dopamine agonists selective for D3 versus D2 receptors. Neuroreport. 1995 Jan 26;6(2):329-32. |
|---|
