Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06DKB
|
||||
| Former ID |
DNC011027
|
||||
| Drug Name |
GNF-PF-4478
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [531262] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H20ClN5O
|
||||
| Canonical SMILES |
C1COCCN1CCCNC2=NC=NC3=C2NC4=C3C=C(C=C4)Cl
|
||||
| InChI |
1S/C17H20ClN5O/c18-12-2-3-14-13(10-12)15-16(22-14)17(21-11-20-15)19-4-1-5-23-6-8-24-9-7-23/h2-3,10-11,22H,1,4-9H2,(H,19,20,21)
|
||||
| InChIKey |
ULJISGNQAXNPOC-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Insulin-degrading Enzyme | Target Info | Inhibitor | [531262] | |
| Cruzipain | Target Info | Inhibitor | [530968] | ||
| KEGG Pathway | Alzheimer's disease | ||||
| WikiPathways | Alzheimers Disease | ||||
| References | |||||
| Ref 530968 | J Med Chem. 2010 Jul 8;53(13):4891-905.Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. | ||||
| Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.