Drug Information

Drug General Information
Drug ID
D06DLQ
Former ID
DIB005941
Drug Name
CGP-37849
Synonyms
CGP-39551; CGP-40116; CGP-43487; Ethyl ester of CGP-37849; 4-methyl-APPA
Drug Type
Small molecular drug
Indication Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10:I21, I22, R52, R52.1-R52.2, R60.9, G89] Discontinued in Phase 1 [467499], [546401]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL
Formula
C6H12NO5P
InChI
InChI=1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChIKey
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
PubChem Compound ID
5950212
PubChem Substance ID
11852413, 15121141, 40491449, 50003082, 57365307, 75143422, 91746273, 103200249, 114249370, 135062065, 135306572, 137013862, 144240202, 170485602, 178100975, 224936602, 227641180, 241182456, 241375453
Target and Pathway
Target(s) NMDA receptor Target Info Modulator [530393]
References
Ref 467499(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4154).
Ref 546401Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007917)
Ref 530393The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents. Naunyn Schmiedebergs Arch Pharmacol. 1990 Jul;342(1):61-6.

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