Drug Information

Drug General Information
Drug ID
D06DUE
Former ID
DIB018387
Drug Name
[3H]quisqualate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538848]
Structure
Download
2D MOL

3D MOL
Formula
C5H7N3O5
InChI
InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKey
ASNFTDCKZKHJSW-REOHCLBHSA-N
PubChem Compound ID
40539
PubChem Substance ID
10494, 829151, 3153217, 7890168, 7980474, 8176644, 11113399, 14867669, 17405597, 17436194, 24278004, 24770702, 26751639, 34706304, 46392526, 46392527, 46392847, 46509075, 46517821, 47170012, 47193871, 47589201, 47736719, 48110694, 50064863, 50104331, 50104332, 53786831, 57312446, 79846616, 85164420, 90341112, 91702071, 92303337, 103195075, 104050226, 104334657, 117593873, 118696079, 121362063, 124750188, 124800475, 127453052, 134344737, 135004298, 135650876, 135651194, 135676646, 135685944, 135697895
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Agonist [526499]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538848(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1370).
Ref 526499Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor. J Biol Chem. 2003 Mar 7;278(10):8340-7. Epub 2002 Dec 30.

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