Drug General Information
Drug ID	D06FCR
Former ID	DIB000982
Drug Name	CL-277082
Drug Type	Small molecular drug
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Discontinued in Phase 1	[544948]
Company	Lederle Laboratories
Structure		Download 2D MOL 3D MOL
Formula	C26H36F2N2O
Canonical SMILES	C(=O)(Nc1c(cc(cc1)F)F)N(Cc1ccc(CC(C)(C)C)cc1)CCCCCCC
CAS Number	CAS 96224-26-9
PubChem Compound ID	125893
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[533344]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 544948	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001648)
Ref 533344	CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90.

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