Drug General Information |
Drug ID |
D06FLU
|
Former ID |
DNC007401
|
Drug Name |
3,8-dibromoboldine
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C19H19Br2NO4
|
Canonical SMILES |
CN1CCC2=C(C(=C(C3=C2C1CC4=C(C(=C(C=C43)OC)O)Br)OC)O)Br
|
InChI |
1S/C19H19Br2NO4/c1-22-5-4-8-13-11(22)6-10-9(7-12(25-2)17(23)16(10)21)14(13)19(26-3)18(24)15(8)20/h7,11,23-24H,4-6H2,1-3H3/t11-/m0/s1
|
InChIKey |
FTUCKVYWXINSAK-NSHDSACASA-N
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PubChem Compound ID |
|
Target and Pathway |
Target(s) |
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
Dopamine D1 receptor |
Target Info |
Inhibitor |
[1]
|
Neuronal acetylcholine receptor protein, alpha-7 chain |
Target Info |
Inhibitor |
[2]
|
KEGG Pathway
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Rap1 signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Amphetamine addiction
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Morphine addiction
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Cholinergic synapse
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Nicotine addiction
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Chemical carcinogenesis
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
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Nicotinic acetylcholine receptor signaling pathway
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PathWhiz Pathway
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Dopamine Activation of Neurological Reward System
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (s) signalling eventsR-HSA-629594:Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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References |
REF 1 | J Nat Prod. 2000 Apr;63(4):480-4.Halogenated boldine derivatives with enhanced monoamine receptor selectivity. |
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REF 2 | Bioorg Med Chem. 2007 May 15;15(10):3368-72. Epub 2007 Mar 13.Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. |