Drug Information

Drug General Information
Drug ID
D06HCC
Former ID
DIB007060
Drug Name
LANEPITANT
Synonyms
LY-303870; LY-302654 (racemate); Lanepitant < Prop INN >; N-[1(R)-(1H-Indol-3-ylmethyl)-2-[N-(2-methoxybenzyl)acetamido]ethyl]-2-[4-(1-piperidinyl)piperidin-1-yl]acetamide
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 2 [540448], [546075]
Structure
Download
2D MOL

3D MOL
Formula
C33H45N5O3
InChIKey
CVXJAPZTZWLRBP-MUUNZHRXSA-N
CAS Number
CAS 170566-84-4
PubChem Compound ID
3086681
PubChem Substance ID
7979823, 9472226, 14764005, 14910869, 36416409, 49894512, 57356034, 77866263, 103222652, 103979673, 111695388, 127685592, 135236371, 178100496, 179150055, 198954428, 226492961
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [532961], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540448(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3510).
Ref 546075Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006197)
Ref 532961NK1 receptor antagonists as a new treatment for corneal neovascularization. Invest Ophthalmol Vis Sci. 2014 Sep 16;55(10):6783-94.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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