Drug Information

Drug General Information
Drug ID
D06HEY
Former ID
DNCL003454
Drug Name
CTL019
Indication Chronic lymphocytic leukaemia [ICD10:C91] Phase 2 [525190]
Company
Novartis Pharmaceuticals; University of Pennsylvania
Target and Pathway
Target(s) B-lymphocyte antigen CD19 Target Info Modulator [551967]
KEGG Pathway PI3K-Akt signaling pathway
Hematopoietic cell lineage
B cell receptor signaling pathway
Epstein-Barr virus infection
Primary immunodeficiency
NetPath Pathway IL-7 Signaling Pathway
PANTHER Pathway B cell activation
Pathway Interaction Database BCR signaling pathway
Reactome PIP3 activates AKT signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Constitutive Signaling by Aberrant PI3K in Cancer
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways Human Complement System
Signaling by the B Cell Receptor (BCR)
PIP3 activates AKT signaling
B Cell Receptor Signaling Pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 525190ClinicalTrials.gov (NCT02445248) Study of Efficacy and Safety of CTL019 in Adult DLBCL Patients. U.S. National Institutes of Health.
Ref 551967Clinical pipeline report, company report or official report of Novartis.

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