Drug Information

Drug General Information
Drug ID
D06HHJ
Former ID
DNC004340
Drug Name
(2-Bromo-phenyl)-(1H-imidazol-2-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534315]
Structure
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2D MOL

3D MOL
Formula
C9H8BrN3
Canonical SMILES
C1=CC=C(C(=C1)NC2=NC=CN2)Br
InChI
1S/C9H8BrN3/c10-7-3-1-2-4-8(7)13-9-11-5-6-12-9/h1-6H,(H2,11,12,13)
InChIKey
KHNAVCNEASQADL-UHFFFAOYSA-N
PubChem Compound ID
10490084
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [534315]
Alpha-2C adrenergic receptor Target Info Inhibitor [534315]
Alpha-1A adrenergic receptor Target Info Inhibitor [534315]
Alpha-2A adrenergic receptor Target Info Inhibitor [534315]
Alpha-1B adrenergic receptor Target Info Inhibitor [534315]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR downstream signalingWP58:Monoamine GPCRs
Endothelin Pathways
AMPK SignalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK Signaling
References
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.

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