Drug Information

Drug General Information
Drug ID
D06HMI
Former ID
DCL000924
Drug Name
PF-00547659
Drug Type
Antibody
Indication Ulcerative colitis; Inflammatory bowel disease [ICD9: 555, 556, 556.9; ICD10:K50, K50-K52, K51] Phase 2 [536371]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C21H23N3O5
Canonical SMILES
CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(<br />C)C
InChI
1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
InChIKey
RXIUEIPPLAFSDF-CYBMUJFWSA-N
PubChem Compound ID
9865554
PubChem Substance ID
14830309, 15239529, 24157557, 45287820, 49684245, 57373598, 75326444, 103504099, 104080923, 134339147, 134339370, 134339414, 139202936, 144226108, 152255044, 152258116, 160646955, 160828641, 163093649, 163390348, 163842451, 184826585, 204431411, 225375150, 226544916, 246120473, 252166705
Target and Pathway
Target(s) Mucosal addressin cell adhesion molecule 1 Target Info [536371]
KEGG Pathway Cell adhesion molecules (CAMs)
Intestinal immune network for IgA production
NetPath Pathway TNFalpha Signaling Pathway
Pathway Interaction Database a4b7 Integrin signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
References
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.
Ref 536371Emerging drugs to treat Crohn's disease. Expert Opin Emerg Drugs. 2007 Mar;12(1):49-59.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.