Drug General Information
Drug ID	D06HZA
Former ID	DNCL003580
Drug Name	GSK2586184
Synonyms	GSK-2586184
Indication	Systemic lupus erythematosus [ICD9: 710; ICD10:M32]		Phase 2	[524199]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	JAK1	Target Info	Modulator	[533157]
KEGG Pathway	PI3K-Akt signaling pathway
	Osteoclast differentiation
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Hepatitis B
	Measles
	Influenza A
	HTLV-I infection
	Herpes simplex infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Pancreatic cancer
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Angiogenesis
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
Pathway Interaction Database	p73 transcription factor network
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by TCPTP
	SHP2 signaling
	IL2-mediated signaling events
	IL2 signaling events mediated by PI3K
	IFN-gamma pathway
	IL6-mediated signaling events
	PDGFR-alpha signaling pathway
	IL2 signaling events mediated by STAT5
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	ISG15 antiviral mechanism
	Interleukin-7 signaling
	G beta:gamma signalling through PI3Kgamma
	Interleukin-2 signaling
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interferon alpha/beta signaling
	Interleukin receptor SHC signaling
	Regulation of IFNA signaling
WikiPathways	Type II interferon signaling (IFNG)
	Interferon type I signaling pathways
	TGF Beta Signaling Pathway
	IL-2 Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
	IL-3 Signaling Pathway
	Interleukin-2 signaling
	Interleukin-7 signaling
	JAK/STAT
	PDGF Pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	Prostate Cancer
	TSLP Signaling Pathway
	IL-9 Signaling Pathway
	Type III interferon signaling
	IL17 signaling pathway
	IL-7 Signaling Pathway
	Leptin signaling pathway
	TSH signaling pathway
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Interferon alpha/beta signaling
	IL-5 Signaling Pathway
References
Ref 524199	ClinicalTrials.gov (NCT01777256) An Adaptive Phase II Study to Evaluate the Efficacy, Pharmacodynamics, Safety and Tolerability of GSK2586184. U.S. National Institutes of Health.
Ref 533157	DRESS syndrome and reversible liver function abnormalities in patients with systemic lupus erythematosus treated with the highly selective JAK-1 inhibitor GSK2586184. Lupus. 2015 May;24(6):648-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.