Drug Information

Drug General Information
Drug ID
D06IAR
Former ID
DAP000223
Drug Name
Adenosine
Synonyms
ADN; Adenocard; Adenocor; Adenoscan; Adenosin; Adensoine; Boniton; Myocol; Nucleocardyl; Pallacor;Polyadenosine; Polyriboadenosine; Sandesin; Vidarabine; Adenine nucleoside; Adenine riboside; Adenosin [German]; SR 96225; Ade-Rib; Adenocard (TN); Adenocard, Adenosine; Adenoscan (TN); Adenosine [USAN:BAN]; Adenosine, homopolymer; Beta-Adenosine; MEDR-640; SR-96225; SUN-Y4001; USAF CB-10; Adenine-D-ribose; Adenosine (JAN/USP); Beta-D-Adenosine; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
Drug Type
Small molecular drug
Indication Paroxysmal supraventricular tachycardia [ICD9: 427, 427.0, 427.1, 427.89, 785.0; ICD10:I47-I49, I47.1, I47.2, R00.0] Approved [536838], [539879]
Therapeutic Class
Antiarrhythmic Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H13N5O4
InChI
InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKey
OIRDTQYFTABQOQ-KQYNXXCUSA-N
CAS Number
CAS 58-61-7
PubChem Compound ID
60961
PubChem Substance ID
2103, 3512, 584484, 584490, 585862, 586357, 597013, 819854, 821994, 823447, 825728, 826920, 828107, 828519, 829493, 830178, 830391, 833174, 833907, 836875, 837192, 855078, 855932, 3136392, 7847113, 7885717, 7978645, 8023217, 8024149, 8027268, 8143428, 8187141, 10318629, 11110168, 11120317, 11120805, 11121293, 11371396, 11484930, 11489073, 11490104, 11532406, 11532673, 11537606, 12090919, 14716094, 14774851, 14799162, 22394812, 24277685
ChEBI ID
ChEBI:16335
SuperDrug ATC ID
C01EB10
SuperDrug CAS ID
cas=000058617
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Modulator [556264]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536838Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
Ref 539879(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2844).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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