Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D06MUB
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| Former ID |
DIB003695
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| Drug Name |
SMOi2-17
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| Synonyms |
SMOi2-20; SMO antagonist (lipidated peptide, cancer), NCI; Smoothened antagonist (lipidated peptide, cancer), NCI
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [543616] | ||
| Company |
National Cancer Institute
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
N([C@@H](C(=O)O)CCCCNC(=O)CCCCCCCCCCCCCCC)C(=O)[C@H](NC<br />(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@<br />H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](N)CC<br />CCN)Cc1ccccc1)CO)[C@@H](O)C)Cc1c[nH]cn1)Cc1c[nH]c2c1ccc<br />c2)C)[C@@H](O)C)Cc1ccc(cc1)O)CC(C)C
|
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| Target and Pathway | |||||
| Target(s) | smoothened receptor | Target Info | Antagonist | [543616] | |
| PANTHER Pathway | Hedgehog signaling pathway | ||||
| Pathway Interaction Database | Signaling events mediated by the Hedgehog family | ||||
| Hedgehog signaling events mediated by Gli proteins | |||||
| References | |||||
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