Drug General Information
Drug ID	D06NDT
Former ID	DNC008427
Drug Name	3-(3-hydroxyphenyl)quinolin-7-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529359]
Structure		Download 2D MOL 3D MOL
Formula	C15H11NO2
Canonical SMILES	C1=CC(=CC(=C1)O)C2=CNC3=CC(=O)C=CC3=C2
InChI	1S/C15H11NO2/c17-13-3-1-2-10(7-13)12-6-11-4-5-14(18)8-15(11)16-9-12/h1-9,16-17H
InChIKey	FEFXFNLGBUGJSX-UHFFFAOYSA-N
PubChem Compound ID	24827433
Target and Pathway
Target(s)	Estradiol 17 beta-dehydrogenase 1	Target Info	Inhibitor	[529359]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	The canonical retinoid cycle in rods (twilight vision)
WikiPathways	Steroid Biosynthesis
	Metabolism of steroid hormones and vitamin D
	Prostate Cancer
References
Ref 529359	J Med Chem. 2008 Apr 10;51(7):2158-69. Epub 2008 Mar 7.Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Ref 529359	J Med Chem. 2008 Apr 10;51(7):2158-69. Epub 2008 Mar 7.Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.

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