Drug General Information
Drug ID
D06NGR
Former ID
DNC003448
Drug Name
7-Methyl-Gpppa
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
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2D MOL

3D MOL

Formula
C21H30N10O17P3+
Canonical SMILES
CN1C=[N+](C2=C1C(=O)N=C(N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O<br />)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=CN=C6N)O)O)O)O
InChI
1S/C21H29N10O17P3/c1-29-6-31(17-10(29)18(36)28-21(23)27-17)20-14(35)12(33)8(46-20)3-44-50(39,40)48-51(41,42)47-49(37,38)43-2-7-11(32)13(34)19(45-7)30-5-26-9-15(22)24-4-25-16(9)30/h4-8,11-14,19-20,32-35H,2-3H2,1H3,(H7-,22,23,24,25,27,28,36,37,38,39,40,41,42)/p+1/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1
InChIKey
QQOHNVHGNZYSBP-XPWFQUROSA-O
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mRNA of Eukaryotic translation initiation factor 4E Target Info Inhibitor [551393]
KEGG Pathway RNA transport
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Insulin signaling pathway
PANTHER Pathway p38 MAPK pathway
CCKR signaling map ST
Pathway Interaction Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Validated targets of C-MYC transcriptional activation
mTOR signaling pathway
Signaling mediated by p38-alpha and p38-beta
PathWhiz Pathway Leucine Stimulation on Insulin Signaling
Reactome ISG15 antiviral mechanism
mTORC1-mediated signalling
WikiPathways Interferon type I signaling pathways
Hypertrophy Model
Insulin Signaling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
ISG15 antiviral mechanism
Deadenylation-dependent mRNA decay
Structural Pathway of Interleukin 1 (IL-1)
BDNF signaling pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Signaling by Insulin receptor
Processing of Capped Intron-Containing Pre-mRNA
Eukaryotic Translation Initiation
Translation Factors
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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