Drug Information

Drug General Information
Drug ID
D06NMZ
Former ID
DNC001052
Drug Name
NVP-ADW742
Drug Type
Small molecular drug
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Investigative [537114]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C28H31N5O
Canonical SMILES
C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6<br />=CC=CC=C6
InChI
1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)
InChIKey
LSFLAQVDISHMNB-UHFFFAOYSA-N
PubChem Compound ID
9825149
PubChem Substance ID
14784297, 15167856, 24127797, 44923287, 53837761, 74517124, 103550967, 103904996, 104092611, 117695996, 124756989, 125163794, 131480752, 134340305, 136367288, 137778791, 139380001, 140885742, 141546423, 144116293, 152258154, 160646991, 162011873, 162037425, 162202652, 163907941, 164339439, 174006571, 174529497, 180190868, 186014832, 202553532, 223397881, 226472395, 228142956, 228142958, 241377378, 242526284, 242800901, 245990226, 248492712, 251963182, 252110001, 252158717, 252215927, 252437621, 252823856
Target and Pathway
Target(s) Insulin-like growth factor I receptor Target Info Inhibitor [537114]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanoma
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junction
Reactome IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
Ref 537114Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.

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