Drug General Information
Drug ID	D06NPB
Former ID	DND000033
Drug Name	GLPG-0259
Synonyms	G-13919, GT-146, GT-1498, GT-1704, GT-314, GT-416, GT-514, GT-562
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Discontinued in Phase 2	[550825]
Company	Johnson&Johnson
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	MAPKAPK5	Target Info	Inhibitor	[543554]
Pathway Interaction Database	Signaling mediated by p38-alpha and p38-beta
Reactome	Oxidative Stress Induced Senescence
	MAPK6/MAPK4 signaling
WikiPathways	p38 MAPK Signaling Pathway
	MAPK Signaling Pathway
References
Ref 550825	Clinical pipeline report, company report or official report of Galapagos.
Ref 543554	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2096).

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