Drug General Information
Drug ID
D06OMK
Former ID
DAP000162
Drug Name
Tacrolimus
Synonyms
Advagraf; Fujimycin; Graceptor; Modigraf; Prograf; Protopic; Protopy; Tacarolimus; Tsukubaenolide; Tacrolimus anhydrous; FK 506; FK5; FK506; FR 900506; FR900506; K506; L 679934; Advagraf (TN); FR-900506; Fk-506; L-679934; LCP-Tacro; Prograf (TN); Protopic (TN); Tacrolimus (INN); Tacrolimus (Prograf); Tacrolimus (anhydrous); (-)-FK 506; 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN; FK506
Drug Type
Small molecular drug
Indication Organ transplant rejection [ICD9: 279.5, 996; ICD10:D89.8, T86] Approved [537129], [541864]
Ocular allergy [ICD9: 360-379; ICD10:H00-H59] Phase 3 [537129], [541864]
Therapeutic Class
Immunosuppressive Agents
Company
Fujisawa; Sucampo
Structure
Download
2D MOL

3D MOL

Formula
C44H69NO12
InChI
InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChIKey
QJJXYPPXXYFBGM-LFZNUXCKSA-N
CAS Number
CAS 104987-11-3
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
D11AH01; L04AD02
SuperDrug CAS ID
cas=109581933
Target and Pathway
Target(s) Calcineurin Target Info Inhibitor [536119]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Oocyte meiosis
Apoptosis
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Oxytocin signaling pathway
Glucagon signaling pathway
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Tuberculosis
HTLV-I infection
Reactome DARPP-32 events
FCERI mediated Ca+2 mobilization
Ca2+ pathway
WikiPathways Mitochondrial Gene Expression
MAPK Signaling Pathway
G Protein Signaling Pathways
Cardiac Hypertrophic Response
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
T-Cell Receptor and Co-stimulatory Signaling
Amyotrophic lateral sclerosis (ALS)
Spinal Cord Injury
Alzheimers Disease
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
Opioid Signalling
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 541864(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6784).
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.

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