Drug General Information
Drug ID	D06PHH
Former ID	DIB007628
Drug Name	Rimacalib
Synonyms	SMP-114
Drug Type	Small molecular drug
Indication	Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06]		Phase 2	[544378]
Company	Sumitomo Pharmaceuticals Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C22H23FN4O2
Canonical SMILES	N(C(=N)N1CCOCC1)c1cc(no1)[C@H](c1cc(c(cc1)c1ccccc1)F)C
CAS Number	CAS 215174-50-8
PubChem Compound ID	9800765
Target and Pathway
Target(s)	CaM kinase II	Target Info	Modulator	[530384], [544378]
KEGG Pathway	ErbB signaling pathway
	Calcium signaling pathway
	cAMP signaling pathway
	HIF-1 signaling pathway
	Oocyte meiosis
	Adrenergic signaling in cardiomyocytes
	Wnt signaling pathway
	Circadian entrainment
	Long-term potentiation
	Neurotrophin signaling pathway
	Cholinergic synapse
	Dopaminergic synapse
	Olfactory transduction
	Inflammatory mediator regulation of TRP channels
	Insulin secretion
	GnRH signaling pathway
	Melanogenesis
	Oxytocin signaling pathway
	Glucagon signaling pathway
	Gastric acid secretion
	Amphetamine addiction
	Tuberculosis
	Proteoglycans in cancer
	Glioma
Reactome	HSF1-dependent transactivation
	Trafficking of AMPA receptors
	Ca2+ pathway
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	CREB phosphorylation through the activation of Ras
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascade
	Interferon gamma signaling
WikiPathways	ErbB Signaling Pathway
	Calcium Regulation in the Cardiac Cell
	EGF/EGFR Signaling Pathway
	Myometrial Relaxation and Contraction Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
References
Ref 544378	CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.
Ref 530384	Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. Ann N Y Acad Sci. 2009 Sep;1173:706-11.
Ref 544378	CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21.

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