Drug General Information
Drug ID	D06PZE
Former ID	DNC011124
Drug Name	TAMARIXETIN
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531094]
Structure		Download 2D MOL 3D MOL
Formula	C16H12O7
PubChem Compound ID	5281699
Target and Pathway
Target(s)	Cytochrome P450 1B1	Target Info	Inhibitor	[531094]
BioCyc Pathway	Superpathway of tryptophan utilization
	Superpathway of melatonin degradation
	Melatonin degradation I
KEGG Pathway	Steroid hormone biosynthesis
	Tryptophan metabolism
	Metabolism of xenobiotics by cytochrome P450
	Ovarian steroidogenesis
	Chemical carcinogenesis
	MicroRNAs in cancer
NetPath Pathway	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Estrogen metabolism
	Benzo(a)pyrene metabolism
	Tamoxifen metabolism
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Sulindac Metabolic Pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	miR-targeted genes in adipocytes - TarBase
	Phase 1 - Functionalization of compounds
References
Ref 531094	Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. Epub 2010 Jul 13.Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
Ref 531094	Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. Epub 2010 Jul 13.Selective inhibition of methoxyflavonoids on human CYP1B1 activity.

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