Drug General Information
Drug ID	D06QOJ
Former ID	DIB017034
Drug Name	RS-8359
Synonyms	CS-8359; TUK-9261; TUK-9262; TUK-9508
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Discontinued in Phase 2	[544693]
Company	Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C14H12N4O
Canonical SMILES	c12c(ncnc1C(CC2)O)Nc1ccc(C#N)cc1
CAS Number	CAS 105365-76-2
PubChem Compound ID	164116
Target and Pathway
Target(s)	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[536146]
BioCyc Pathway	Superpathway of tryptophan utilization
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation II
KEGG Pathway	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholism
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine Metabolism
Reactome	Norepinephrine Neurotransmitter Release Cycle
WikiPathways	SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Dopamine metabolism
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter Activity
References
Ref 544693	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000633)
Ref 536146	Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase. Xenobiotica. 2005 Jun;35(6):561-73.

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