Drug Information

Drug General Information
Drug ID
D06QOX
Former ID
DNC011514
Drug Name
1,3-Diphenyl-1H-chromeno[4,3-c]pyrazol-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533354]
Structure
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2D MOL

3D MOL
Formula
C22H14N2O2
Canonical SMILES
C1=CC=C(C=C1)C2=NN(C3=C2C(=O)OC4=CC=CC=C43)C5=CC=CC=C5
InChI
1S/C22H14N2O2/c25-22-19-20(15-9-3-1-4-10-15)23-24(16-11-5-2-6-12-16)21(19)17-13-7-8-14-18(17)26-22/h1-14H
InChIKey
ZPXTZMAWXDLUOO-UHFFFAOYSA-N
PubChem Compound ID
13448492
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [533354]
Gamma-aminobutyric acid receptor Target Info Inhibitor [533354]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [533354]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 533354J Med Chem. 1988 Jan;31(1):1-3.Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ligands.
Ref 533354J Med Chem. 1988 Jan;31(1):1-3.Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ligands.

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