Drug General Information
Drug ID
D06SDP
Former ID
DPR000073
Drug Name
Melanotetan II
Drug Type
Small molecular drug
Indication Sexual dysfunction; Obesity; Type 2 diabetes [ICD9: 250, 250.00, 250.02, 278, 302.7; ICD10:E08-E13, E11, E66, F52] Preclinical [536122]
Company
Clinuvel Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C18H17ClO6
Canonical SMILES
CC1CC2C(O2)C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
InChI
1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1
InChIKey
WYZWZEOGROVVHK-GTMNPGAYSA-N
CAS Number
CAS 121062-08-6
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Agonist [536122]
Melanocortin-3 receptor Target Info Agonist [536122]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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