Drug General Information
Drug ID	D06SME
Former ID	DNC010929
Drug Name	5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530979]
Structure		Download 2D MOL 3D MOL
Formula	C11H11NO4S
Canonical SMILES	CC1=CC=C(C=C1)S(=O)(=O)N2C(C=CC2=O)O
InChI	1S/C11H11NO4S/c1-8-2-4-9(5-3-8)17(15,16)12-10(13)6-7-11(12)14/h2-7,10,13H,1H3
InChIKey	LASNBXWNXQRYSO-UHFFFAOYSA-N
PubChem Compound ID	46871781
Target and Pathway
Target(s)	Carbonic anhydrase I	Target Info	Inhibitor	[530979]
	Carbonic anhydrase II	Target Info	Inhibitor	[530979]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530979	Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. Epub 2010 May 28.A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.
Ref 530979	Bioorg Med Chem. 2010 Jun 15;18(12):4468-74. Epub 2010 May 28.A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.

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