Drug General Information
Drug ID
D06UAX
Former ID
DNC007910
Drug Name
KYS-05080
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529566]
Structure
Download
2D MOL

3D MOL

Formula
C39H45N5O
Canonical SMILES
CN(CCCCCN1CCCC1)C2=NC3=CC=CC=C3C(N2C4=CC=C(C=C4)C5=CC=C<br />C=C5)CC(=O)NCC6=CC=CC=C6
InChI
1S/C39H45N5O/c1-42(25-11-4-12-26-43-27-13-14-28-43)39-41-36-20-10-9-19-35(36)37(29-38(45)40-30-31-15-5-2-6-16-31)44(39)34-23-21-33(22-24-34)32-17-7-3-8-18-32/h2-3,5-10,15-24,37H,4,11-14,25-30H2,1H3,(H,40,45)
InChIKey
SXLKSZQOUGOJGV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel alpha-1G subunit Target Info Inhibitor [529566]
Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [528495]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
Type II diabetes mellitushsa04010:MAPK signaling pathway
PANTHER Pathway Endogenous cannabinoid signaling
GABA-B receptor II signaling
Nicotine pharmacodynamics pathway
Pathway Interaction Database Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways NCAM signaling for neurite out-growth
Nicotine Activity on Chromaffin CellsWP2355:Corticotropin-releasing hormone
References
Ref 529566Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Ref 528495Bioorg Med Chem Lett. 2007 Jan 15;17(2):471-5. Epub 2006 Oct 12.Synthesis and biological evaluation of novel T-type calcium channel blockers.
Ref 529566Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.

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