Drug Information

Drug General Information
Drug ID
D06UDO
Former ID
DAP001073
Drug Name
Phenindamine
Synonyms
Fenindamina; Phenindaminum; Phenindiamine; Thephorin; NU 1504; Fenindamina [INN-Spanish]; Nolahist (TN); Phenindamine (INN); Phenindamine [INN:BAN]; Phenindaminum [INN-Latin]; Thephorin (TN); 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine; 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-lH-indeno(2,1-c)pyridine; 2,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine; 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine; 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Drug Type
Small molecular drug
Indication Common cold; Allergies [ICD9: 460, 995.3; ICD10:J00, T78.4] Approved [550767]
Therapeutic Class
Antihistamines
Company
Amarin Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H19N
Canonical SMILES
CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4
InChI
1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3
InChIKey
ISFHAYSTHMVOJR-UHFFFAOYSA-N
CAS Number
CAS 82-88-2
PubChem Compound ID
11291
PubChem Substance ID
9992, 5828595, 8158255, 10536692, 14798985, 29279614, 46508187, 47589508, 47662790, 48416411, 49982991, 57326826, 74922133, 85209749, 92729666, 96025040, 103191539, 103987990, 104325684, 125823857, 126680611, 128212933, 134338330, 135021495, 137263871, 142971053, 160964855, 179226015, 217848790, 223440638, 223682358, 226416560, 241151386, 250104383
SuperDrug ATC ID
R06AX04
SuperDrug CAS ID
cas=000082882
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537846]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 550767Drug information of Phenindamine, 2008. eduDrugs.
Ref 537846The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem. 1995 Aug 18;38(17):3351-60.

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