Drug Information

Drug General Information
Drug ID
D06UIU
Former ID
DNC014814
Drug Name
CORYMBONE B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529425]
Structure
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2D MOL

3D MOL
Formula
C31H38O7
Canonical SMILES
CC1=C(C(=C(C(=C1O)C(=O)CCC2=CC=CC=C2)O)C(CC(C)C)C3=C(C(<br />C(=O)C(C3=O)(C)C)(C)C)O)O
InChI
1S/C31H38O7/c1-16(2)15-19(22-27(36)30(4,5)29(38)31(6,7)28(22)37)21-24(33)17(3)25(34)23(26(21)35)20(32)14-13-18-11-9-8-10-12-18/h8-12,16,19,33-36H,13-15H2,1-7H3
InChIKey
LCFIVEWYLOYPOX-UHFFFAOYSA-N
PubChem Compound ID
24878741
Target and Pathway
Target(s) Thyrotropin-releasing hormone receptor Target Info Inhibitor [529425]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Thyrotropin-releasing hormone receptor signaling pathway
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 529425J Nat Prod. 2008 May;71(5):881-3. Epub 2008 Apr 16.Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.
Ref 529425J Nat Prod. 2008 May;71(5):881-3. Epub 2008 Apr 16.Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.

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