Drug Information

Drug General Information
Drug ID
D06VCN
Former ID
DPR000133
Drug Name
Denagliptin
Synonyms
GW 823093; GW823093; (2S,4S)-1-[(2S)-2-amino-3,3-bis(4-fluorophenyl)propanoyl]-4-fluoro-pyrrolidine-2-carbonitrile
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Phase 2/3 [521900]
Company
Glaxo Smithkline
Structure
Download
2D MOL

3D MOL
Formula
C20H18F3N3O
Canonical SMILES
C1C(CN(C1C#N)C(=O)C(C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)N)F
InChI
1S/C20H18F3N3O/c21-14-5-1-12(2-6-14)18(13-3-7-15(22)8-4-13)19(25)20(27)26-11-16(23)9-17(26)10-24/h1-8,16-19H,9,11,25H2/t16-,17-,19-/m0/s1
InChIKey
URRAHSMDPCMOTH-LNLFQRSKSA-N
PubChem Compound ID
9887755
PubChem Substance ID
15275571, 24174009, 45634694, 77268857, 135207591, 139393434, 198971268, 226976588, 242549666, 244438717, 252215262
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [537022]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 521900ClinicalTrials.gov (NCT00387972) Study Of Denagliptin In Subjects With Type 2 Diabetes Mellitus (T2DM). U.S. National Institutes of Health.
Ref 537022Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of Type 2 Diabetes. Curr Drug Targets. 2009 Jan;10(1):71-87.

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