Drug Information

Drug General Information
Drug ID
D06VMV
Former ID
DIB002304
Drug Name
BHF-177
Synonyms
Allosteric GABA B receptor modulators, Novartis; BHF-177; CGP-13501; CGP-7930; CPG-37656; GS-39783
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Investigative [542785]
Company
Novartis AG
Structure
Download
2D MOL

3D MOL
Formula
C19H20F3N3
InChI
InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1
InChIKey
ADHZHPOKTRHZGT-DXCKQFNASA-N
PubChem Compound ID
56940925
PubChem Substance ID
135643138, 164135640, 172650579, 178102149, 198954900, 229164955, 246212742, 247100123, 251962997
Target and Pathway
Target(s) Gamma-aminobutyric acid B receptor Target Info Modulator [543621]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
GABAergic synapse
Estrogen signaling pathway
Morphine addiction
Reactome Activation of G protein gated Potassium channels
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
GPCR ligand binding
GPCR downstream signaling
References
Ref 542785(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7848).
Ref 543621(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 241).

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