| Drug General Information |
| Drug ID |
D06WLB
|
| Former ID |
DNC003798
|
| Drug Name |
Benzyl-[2-(1H-indol-4-yloxy)-ethyl]-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C17H18N2O
|
| Canonical SMILES |
C1=CC=C(C=C1)CNCCOC2=CC=CC3=C2C=CN3
|
| InChI |
1S/C17H18N2O/c1-2-5-14(6-3-1)13-18-11-12-20-17-8-4-7-16-15(17)9-10-19-16/h1-10,18-19H,11-13H2
|
| InChIKey |
ZEHDEZWEFBOGNZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
|
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Gap junction
|
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Dopaminergic synapse
|
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP58:Monoamine GPCRs
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|
GPCRs, Other
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| References |
| REF 1 | Bioorg Med Chem Lett. 1999 Sep 6;9(17):2593-8.New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template. |
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