Drug General Information
Drug ID	D06WOJ
Former ID	DIB002559
Drug Name	JTH-601
Synonyms	JTH-601-G-1
Indication	Prostate disease [ICD10:N42.9]		Discontinued in Phase 2	[546856]
Company	Japan Tobacco Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(c(c(c(c1C)O)C)C)OC)CN(CCOc1c(cc(c(c1)C)O)C(C)C)C.C<br />(=O)(/C=C/C(=O)O)O
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Antagonist	[525752]
	Alpha-2C adrenergic receptor	Target Info	Antagonist	[525752]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
References
Ref 546856	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010685)
Ref 525752	Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30.

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