Drug General Information
Drug ID	D06WUE
Former ID	DNC010972
Drug Name	2,5-dichloro-N-p-tolylthiophene-3-sulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551239]
Structure		Download 2D MOL 3D MOL
Formula	C11H9Cl2NO2S2
Canonical SMILES	CC1=CC=C(C=C1)NS(=O)(=O)C2=C(SC(=C2)Cl)Cl
InChI	1S/C11H9Cl2NO2S2/c1-7-2-4-8(5-3-7)14-18(15,16)9-6-10(12)17-11(9)13/h2-6,14H,1H3
InChIKey	OQWXAWNHXDPWGS-UHFFFAOYSA-N
PubChem Compound ID	49798484
Target and Pathway
Target(s)	Cyclin-A2	Target Info	Inhibitor	[551239]
	Cell division protein kinase 7	Target Info	Inhibitor	[551239]
	Cyclin-dependent protein kinase Pfmrk	Target Info	Inhibitor	[551239]
KEGG Pathway	DNA replication
	Base excision repair
	Nucleotide excision repair
	Mismatch repair
	Cell cycle
	Hepatitis B
	HTLV-I infectionhsa03022:Basal transcription factors
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
Pathway Interaction Database	Retinoic acid receptors-mediated signaling
PathWhiz Pathway	Nucleotide Excision Repair
Reactome	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	SCF(Skp2)-mediated degradation of p27/p21
	Senescence-Associated Secretory Phenotype (SASP)
	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
	HDR through Homologous Recombination (HRR)
	Processing of DNA double-strand break ends
	Dual Incision in GG-NER
	Dual incision in TC-NER
	Gap-filling DNA repair synthesis and ligation in TC-NER
	G2 Phase
	Orc1 removal from chromatin
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	Cyclin A:Cdk2-associated events at S phase entryR-HSA-427413:NoRC negatively regulates rRNA expression
	Formation of TC-NER Pre-Incision Complex
	Cyclin E associated events during G1/S transition
	Cyclin D associated events in G1
	Cyclin A:Cdk2-associated events at S phase entry
	RNA Polymerase I Transcription Initiation
WikiPathways	Senescence and Autophagy in Cancer
	Mismatch repair
	DNA Replication
	G1 to S cell cycle control
	EGF/EGFR Signaling Pathway
	S Phase
	Nifedipine Activity
	Primary Focal Segmental Glomerulosclerosis FSGS
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Nucleotide Excision Repair
	Telomere Maintenance
	Synthesis of DNA
	Mitotic G1-G1/S phases
	Cell Cycle
	Base Excision RepairWP45:G1 to S cell cycle control
	Eukaryotic Transcription Initiation
	Cardiac Hypertrophic Response
	HIV Life Cycle
	Integrated Breast Cancer Pathway
	RNA Polymerase II Transcription
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	mRNA Capping
	Mitotic G2-G2/M phases
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 551239	Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).
Ref 551239	Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).

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