Drug Information

Drug General Information
Drug ID
D06WUK
Former ID
DIB014526
Drug Name
Carlumab
Synonyms
CCL-2; CNTO-888; Anti-MCP1 monoclonal antibodies, Centocor; CCL2 monoclonal antibody (infusion, cancer), Centocor
Drug Type
Antibody
Indication Pulmonary fibrosis [ICD9: 515, 516.3; ICD10:J84.1] Phase 2 [532844], [542685]
Company
Janssen biotech
CAS Number
CAS 915404-94-3
Target and Pathway
Target(s) C-C motif chemokine 2 Target Info [532844]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NOD-like receptor signaling pathway
TNF signaling pathway
Chagas disease (American trypanosomiasis)
Malaria
Influenza A
Herpes simplex infection
Rheumatoid arthritis
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL1 Signaling Pathway
TSH Signaling Pathway
TWEAK Signaling Pathway
IL4 Signaling Pathway
TNFalpha Signaling Pathway
TSLP Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
AP-1 transcription factor network
IL23-mediated signaling events
Reactome Chemokine receptors bind chemokines
ATF4 activates genes
WikiPathways IL1 and megakaryotyces in obesity
Activation of Genes by ATF4
Spinal Cord Injury
Oncostatin M Signaling Pathway
TNF alpha Signaling Pathway
TWEAK Signaling Pathway
IL-1 signaling pathway
GPCR ligand binding
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 532844Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study. Target Oncol. 2015 Mar;10(1):111-23.
Ref 542685(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 771).
Ref 532844Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study. Target Oncol. 2015 Mar;10(1):111-23.

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