Drug General Information
Drug ID	D06XAK
Former ID	DIB012919
Drug Name	H-216/44
Drug Type	Small molecular drug
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Terminated	[545911]
Company	Astra AB
Structure		Download 2D MOL 3D MOL
Formula	C25H41N3O6
Canonical SMILES	C(=O)(N1CCC(CC1)O)NCCNCC(COc1ccc(cc1)CCOCCOCC1CC1)O
CAS Number	CAS 108495-27-8
PubChem Compound ID	130141
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[533381]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545911	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005323)
Ref 533381	Binding of the beta-blockers timolol and H 216/44 to ocular melanin. Exp Eye Res. 1988 Oct;47(4):565-77.

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